Publications using the PortaLite
Chronotype predicts working memory-dependent regional cerebral oxygenation under conditions of normal sleep and following a single night of sleep extension
Abstract The aim of this study was to test the hypothesis that the association between sleep duration and brain activation as assessed by regional cerebral oxygenation using near-infrared spectroscopy (NIRS) is dependent on chronotype. Sleep was …
Functional Analysis of Continuous, High-Resolution Measures in Aging Research: A Demonstration Using Cerebral Oxygenation Data From the Irish Longitudinal Study on Aging
Background: A shift towards the dynamic measurement of physiologic resilience and improved technology incorporated into experimental paradigms in aging research is producing high-resolution data. Identifying the most appropriate analysis method for …
Impaired Stabilization of Orthostatic Cerebral Oxygenation Is Associated With Slower Gait Speed: Evidence From The Irish Longitudinal Study on Ageing
Abstract Background Cerebral autoregulation (CAR) systems maintain blood flow to the brain across a wide range of blood pressures. Deficits in CAR have been linked to gait speed (GS) but previous studies had small sample sizes and used specialized …
Intermittent neck flexion induces greater sternocleidomastoid deoxygenation than inspiratory threshold loading
Purpose To compare deoxygenation of the sternocleidomastoid, scalenes, and diaphragm/intercostals (Dia/IC) during submaximal intermittent neck flexion (INF) versus submaximal inspiratory threshold loading (ITL) in healthy adults. Methods Fourteen …
Evaluation of transcutaneous near-infrared spectroscopy for early detection of cardiac arrest in an animal model
Abstract Sudden cardiac arrest (SCA) is a leading cause of mortality worldwide. The SCA-to-resuscitation interval is a key determinant of patient outcomes, highlighting the clinical need for reliable and timely detection of SCA. Near-infrared …
Mild cognitive impairment estimation based on functional near‐infrared spectroscopy
Abstract Patients with mild cognitive impairment (MCI) are at a high risk of developing future dementia. However, early identification and active intervention could potentially reduce its morbidity and the incidence of dementia. Functional …
Ambulatory monitoring of cerebrovascular responses to upright posture and walking in older adults with heart failure
Background Insufficient cardiac output (Q) in individuals with heart failure (HF) limits daily functioning and reduces quality of life. While lower cerebral perfusion, secondary to limitations in Q, has been observed during moderate-intensity …
Structural and functional impairments of skeletal muscle in patients with postacute sequelae of SARS-CoV-2 infection
Several months after mild acute SARS-CoV-2 infection, a substantial proportion of patients present persisting, and often debilitating, symptoms and sequelae. These patients show reduced quality of life due to exercise intolerance, muscle weakness, …
Safety and feasibility of transcutaneous vagus nerve stimulation in mild cognitive impairment: VINCI-AD study protocol
Abstract Background Over 55 million adults are living with dementia globally, which is projected to reach 157 million by 2050. Mild cognitive impairment (MCI), a syndrome of memory impairment with intact activities of daily living, may precede …
A promising tool to explore functional impairment in neurodegeneration: A systematic review of near-infrared spectroscopy in dementia.
his systematic review aimed to evaluate previous studies which used near-infrared spectroscopy (NIRS) in dementia given its suitability as a diagnostic and investigative tool in this population. From 800 identified records which used NIRS in dementia …
The prefrontal cortex hemodynamic responses to dual-task paradigms in older adults: A systematic review and meta-analysis
Background Functional near-infrared spectroscopy (fNIRS) is a method to measure cerebral hemodynamics. Determining the changes in prefrontal cortex (PFC) hemodynamics during dual-task paradigms is essential in explaining alterations in physical …
Reactive hyperemia half-time response is associated with skeletal muscle oxygen saturation changes during cycling exercise
We investigated the relationship between muscle microvascular responses during reactive hyperemia as assessed using near-infrared spectroscopy (NIRS) with changes in skeletal muscle oxygen saturation during exercise. Thirty young untrained adults …
Effects of Posture and Walking on Tibial Vascular Hemodynamics Before and After 14 Days of Head‐Down Bed Rest
Human skeletal hemodynamics remain understudied. Neither assessments in weight-bearing bones during walking nor following periods of immobility exist, despite knowledge of altered nutrient-artery characteristics after short-duration unloading in …
Local microvascular tissue oxygenation of the intrinsic foot muscles in patients with diabetes: A cross-sectional case-comparison study
Background Foot-related complications including impaired peripheral circulation and lower limb ulceration are severe consequences for those with diabetes mellitus. This study aimed to assess differences in tissue oxygenation and oxygen utilization of …
Women Have Greater Endothelin-B Receptor Function and Lower Mitochondrial Capacity Compared to Men With Type 1 Diabetes
Abstract Context Type 1 diabetes (T1D) negatively affects both the endothelin system and muscle oxidative capacity. The endothelin pathway is a critical regulator of microcirculatory function and may exhibit sexual dichotomy by which healthy …
Aerobic capacity and $$dottextVtextO_2$$ kinetics adaptive responses to short-term high-intensity interval training and detraining in untrained females
Purpose: This study investigated the physical fitness and oxygen uptake kinetics (τ[Formula: see text]) along with the O2 delivery and utilization (heart rate kinetics, τHR; deoxyhemoglobin/[Formula: see text] ratio, ∆[HHb]/[Formula: see text]) …
Capturing postural blood pressure dynamics with near-infrared spectroscopy-measured cerebral oxygenation
Abstract Orthostatic hypotension (OH) is highly prevalent in older adults and associated with dizziness, falls, lower physical and cognitive function, cardiovascular disease, and mortality. OH is currently diagnosed in a clinical setting with …
Estimation of Respiratory Rate during Biking with a Single Sensor Functional Near-Infrared Spectroscopy (fNIRS) System
Objective: The employment of wearable systems for continuous monitoring of vital signs is increasing. However, due to substantial susceptibility of conventional bio-signals recorded by wearable systems to motion artifacts, estimation of the …
Impact of reduced weight on motor and cognitive function in astronaut analogs: A simulated lunar gravity workload study
The purpose of this study was to investigate changes in gait patterns, motor dexterity, cognition, neuromuscular performance, neural activation of the prefrontal cortex, and perception of effort and exertion during a 60-min walking trial at a reduced …
Near-Infrared Spectroscopy Demonstrates the Benefit of Erythracytapheresis in Sickle Cell Disease Adult Patients with Cerebral Vasculopathy
Background: Cerebral vasculopathy can induce chronic cerebral hypoperfusion leading to stroke in patients with sickle cell disease (SCD) and is treated by blood exchange transfusion (BET). However, no prospective clinical study has demonstrated the …