Publications using the PortaLite
Impaired microcirculatory function, mitochondrial respiration, and oxygen utilization in skeletal muscle of claudicating patients with peripheral artery disease
Ex vivo skeletal muscle arteriole endothelial function is impaired in claudicating patients with PAD, and this is associated with attenuated skeletal muscle mitochondrial respiration. In vivo skeletal muscle oxygen delivery and utilization capacity …
Improved microvascular reactivity after aged garlic extract intake is not mediated by hydrogen sulfide in older adults at risk for cardiovascular disease: a randomized clinical trial
Purpose: This study aimed to investigate the effects of AGE on microvascular reactivity, systolic blood pressure (SBP), and diastolic blood pressure (DBP) in older individuals at high risk for cardiovascular disease (CVD). Urinary thiosulfate was …
Increased multimorbidity is associated with impaired cerebral and peripheral hemodynamic stabilization during active standing
Background Age-related morbidities and frailty are associated with impaired blood pressure (BP) and heart rate (HR) recovery after standing. Here we investigate how multimorbidity affects cerebral and peripheral hemodynamics during standing in a …
Application of near-infrared spectroscopy in human elite freedivers while deep diving on a single breath hold
Near-infrared spectroscopy was used to observe the cerebral hemodynamic response of freedivers during single breath-hold training dives. We observed variability in hemodynamic progression, and heartbeat shape changes with diving depth.
Changes in prefrontal cerebral oxygenation and microvascular blood volume in hypoxia and possible association with acute mountain sickness
The aim of this study was to evaluate changes in prefrontal cerebral oxygenation and microvascular blood volume during exercise in normobaric hypoxia and to investigate possible associations with the occurrence of acute mountain sickness (AMS) at …
Mild poikilocapnic hypoxia increases very low frequency haemoglobin oxygenation oscillations in prefrontal cortex
Abstract Background The aim of the study was to investigate the effect of mild cerebral hypoxia on haemoglobin oxygenation (HbO 2 ), cerebrospinal fluid dynamics and cardiovascular physiology. To achieve this goal, four signals were recorded …
Decreased automaticity contributes to dual task decrements in older compared to younger adults
Purpose To contrast older and younger adults’ prefrontal cortex (PFC) neural activity (through changes in oxygenated hemoglobin) during single and dual tasks, and to compare decrements in task performance. Methods Changes in oxygenated hemoglobin of …
Determinants of orthostatic cerebral oxygenation assessed using near-infrared spectroscopy
Background To understand the relationship between blood pressure changes during standing up and clinical outcome, cerebral oxygenation needs to be measured, which may be performed using near-infrared spectroscopy (NIRS). However, the role of …
Effects of passive and active leg movements to interrupt sitting in mild hypercapnia on cardiovascular function in healthy adults
Prolonged sitting in a mild hypercapnic environment impairs peripheral vascular function. The effects of sitting interruptions using passive or active skeletal muscle contractions are still unclear. Therefore, we sought to examine the vascular …
Leg Fidgeting Improves Executive Function following Prolonged Sitting with a Typical Western Meal: A Randomized, Controlled Cross-Over Trial
Prolonged uninterrupted sitting and a typical Western meal, high in fat and refined sugar, can additively impair cognitive and cerebrovascular functions. However, it is unknown whether interrupting these behaviours, with a simple desk-based activity, …
Optimized electroencephalogram and functional near-infrared spectroscopy-based mental workload detection method for practical applications
Abstract Background Mental workload is a critical consideration in complex man–machine systems design. Among various mental workload detection techniques, multimodal detection techniques integrating electroencephalogram (EEG) and functional …
Acute Effects of Local Ischemic Hypoxia and Systemic Hypoxemia on Neuromuscular and Cognitive Function
Background: The application of blood flow restriction (BFR) induces local ischemic hypoxia within the muscle(s) distal to the restriction device. Systemic hypoxemia via oxygen or barometric pressure manipulation achieves whole-body hypoxia and thus …
Frailty influences the vascular responsiveness of elderly individuals with chronic heart failure
Introduction Frailty is highly prevalent in heart failure (HF) patients. HF is associated with oxidative stress and chronic inflammation, which impair oxygen use by skeletal muscles. Little is known about the influence of frailty on vascular …
Handgrip exercise induces sex‐specific mean arterial pressure and oxygenation responses but similar performance fatigability
Women exhibit an attenuated exercise pressor reflex (EPR) when compared to men. The influence of sex-specific mechanisms related to the EPR and performance fatigability remain to be fully elucidated. The purpose was to determine the impact of …
The influence of cardiovascular risk factors on near-infrared spectroscopy-derived muscle oxygen saturation during exercise recovery in older adults
Purpose Aging is typically accompanied by risk for cardiovascular disease (CVD), which both are associated with reduced muscle oxygen saturation (SmO2) during exercise recovery. However, the apart impact of aging and CVD risk factors on muscle …
Turmeric root extract supplementation improves pre-frontal cortex oxygenation and blood volume in older males and females: a randomised cross-over, placebo-controlled study
Ageing is associated with endothelial dysfunction and reduced cerebral blood flow and oxygenation. The present study aimed to investigate whether turmeric supplementation could improve cerebral oxygenation and blood volume during brain activation via …
Hemodynamic and structural brain measures in high and low sedentary older adults
Due to its cardiovascular effects sedentary behaviour might impact cerebrovascular function in the long term, affecting cerebrovascular regulatory mechanisms and perfusion levels. Consequently this could underly potential structural brain …
Approximate entropies of resting state continuous neurocardiovascular physiological signals are associated with physical frailty in older adults
Frailty in older adults is characterised by dysregulation in multiple physiological systems. The frailty phenotype is defined on the basis of exhaustion, unexplained weight loss, weakness, slowness and low physical activity (one or two: pre-frail; 3 …
Arterial Stiffness Responses to Prolonged Sitting Combined with a High Glycemic Index Meal: A Double-Blind, Randomized Cross-Over Trial
Regular exposure to uninterrupted prolonged sitting and the consumption of high glycemic meals (HGI) is independently associated with increased cardiovascular disease risk. Sitting for as little as 1-hour can impair the health of both peripheral and …
Cerebrovascular function response to prolonged sitting combined with a high‐glycemic index meal: A double‐blind, randomized cross‐over trial
Acute prolonged sitting leads to cerebrovascular disruptions. However, it is unclear how prolonged sitting interacts with other common behaviors, including high- (HGI) and low- glycemic index (LGI) meals. Using a double- blind randomized cross- over …