This study investigated the effects of four exposures to normobaric hypoxia (SIH group; FIO2=0.120, N= 10) or placebo-control normoxia (Control group; FI O2=0.209, N= 9) on cardio-respiratory responses to hypoxic exercise. Before and after the exposures all subjects performed a constant power test (CP) to exhaustion in hypoxia (FI O2=0.120) at a work load corresponding to 75% of previously determined normoxic V O2 peak. Arterial oxygen saturation (Sp O2) and minute ventilation (V E) were measured continuously. NIRS was used to monitor regional changes in oxygenated, de-oxygenated and total hemoglobin concentrations of the frontal cortex, vastus lateralis and serratus anterior. Although neither group improved CP time, the SIH group exhibited increases in both V E (+15%; P< 0.05) and Sp O2 (+4%; P< 0.05) after intermittent hypoxia. No physiologically significant differences were observed during exercise in vastus lateralis, serratus anterior and cerebral oxygenation between groups and testing periods. These data suggest that normobaric SIH enhances hypoxic exercise V E and Sp O2, without affecting regional oxygenation or time to exhaustion. © 2012 Elsevier B.V.