Turmeric root extract supplementation improves pre-frontal cortex oxygenation and blood volume in older males and females: a randomised cross-over, placebo-controlled study

Ageing is associated with endothelial dysfunction and reduced cerebral blood flow and oxygenation. The present study aimed to investigate whether turmeric supplementation could improve cerebral oxygenation and blood volume during brain activation via …

Hair glucocorticoids and resting-state frontal lobe oxygenation: Findings from The Irish Longitudinal Study on Ageing

Cerebral blood flow and oxygenation are crucial for maintaining healthy brain structure and function, with hypoperfusion and hypometabolism associated with neurodegenerative and neuropsychiatric conditions. Chronic stress and elevated cortisol have …

Age and sex differences in frontal lobe cerebral oxygenation in older adults—Normative values using novel, scalable technology: Findings from the Irish Longitudinal Study on Ageing (TILDA)

Aims: Near-infrared spectroscopy (NIRS) is a non-invasive, easy to apply, optical technology for measuring cerebral blood oxygenation, but there is lack of comprehensive population data to aid interpretation and clinical use. Given the importance of …

Cognitive performance is associated with cerebral oxygenation and peripheral oxygen saturation, but not plasma catecholamines, during graded normobaric hypoxia

New Findings: What is the central question of this study? What are the mechanisms responsible for the decline in cognitive performance following exposure to acute normobaric hypoxia? What are the main findings and their importance? We found that (1) …

Impact of carbohydrate ingestion on cognitive flexibility and cerebral oxygenation during high-intensity intermittent exercise: A comparison between maple products and usual carbohydrate solutions

Background: The aim of this study was to compare the effects of carbohydrate (CHO) drinks (6% per volume) sweetened with maple (syrup or sap) to a commercial sports drink, glucose, and a control solution (water) on cognitive flexibility during …

Pregnancy and post-partum muscle and cerebral oxygenation during intermittent exercise in gestational diabetes: A pilot study

Objective: This pilot, prospective, observational, cohort study aimed to examine, for the first time, the in vivo alterations in the oxygenation of the forearm skeletal muscles and the prefrontal lobes during intermittent exercise in women diagnosed …

Repeated treadmill sprints impair cognitive performance in amateur team-sport athletes when performed in normobaric hypoxia

This study determined if a single bout of repeated-sprint running under hypoxic (RSH) conditions was associated with impaired cognitive function when compared with repeated-sprint running under normoxic (RSN) conditions. Eleven amateur team-sport …

Working memory, cognitive load and cardiorespiratory fitness: Testing the CRUNCH model with near-infrared spectroscopy

The present study aimed to examine the effects of chronological age and cardiorespiratory fitness (CRF) on cognitive performance and prefrontal cortex activity, and to test the compensation-related utilization of neural circuits hypothesis (CRUNCH). …

Impaired cerebral oxygenation and exercise tolerance in patients with severe obstructive sleep apnea syndrome

Objective and background: Impaired cerebral blood flow and cerebrovascular reactivity to hypercapnia during wakefulness at rest as well as reduced exercise tolerance have been reported in severe obstructive sleep apnea (OSA) patients. Impaired …

Blunted cerebral oxygenation during exercise in women with gestational diabetes mellitus: associations with macrovascular function and cardiovascular risk factors

Aim/Hypothesis: This cross-sectional, observational, controlled study examined cerebral oxygenation during exercise, an index of cerebrovascular function and cortical activation, in pregnancies complicated by gestational diabetes mellitus (GDM) and …

A comparison of head motion and prefrontal haemodynamics during upright and recumbent cycling exercise

The aim of this observational study was to compare head motion and prefrontal haemodynamics during exercise using three commercial cycling ergometers. Participants (n = 12) completed an incremental exercise test to exhaustion during upright, …

T2-prepared velocity selective labelling: A novel idea for full-brain mapping of oxygen saturation

Background and aim: Disturbances in cerebral oxygenation saturation (SO2) have been linked to adverse outcome in adults, children, and neonates. In intensive care, the cerebral SO2 is increasingly being monitored by Near-InfraRed Spectroscopy (NIRS). …

Effects of brief aquatic exercise in multiple sclerosis on mobility and function

Background: Multiple sclerosis is a demyelinating disorder that impacts mobility and function. The benefits of exercise on multiple sclerosis symptoms have been demonstrated. Exercise is proven to increase cerebral blood flow, and improve oxygen …

Pushing to the limits: The dynamics of cognitive control during exhausting exercise

This study aimed at investigating concurrent changes in cognitive control and cerebral oxygenation (Cox) during steady intense exercise to volitional exhaustion. Fifteen participants were monitored using prefrontal near-infrared spectroscopy and …

Cerebral blood flow and oxygenation at maximal exercise: The effect of clamping carbon dioxide

During exercise, as end-tidal carbon dioxide (PETCO2) drops after the respiratory compensation point (RCP), so does cerebral blood flow velocity (CBFv) and cerebral oxygenation. This low-flow, low-oxygenation state may limit work capacity. We …

Does cerebral oxygen delivery limit incremental exercise performance?

Previous studies have suggested that a reduction in cerebral oxygen delivery may limit motor drive, particularly in hypoxic conditions, where oxygen transport is impaired. We hypothesized that raising end-tidal PCO 2 (PETCO 2) during incremental …

Cerebral oxygenation responses to standing in elderly patients with predominantly diastolic dysfunction

Patients with left ventricular dysfunction may have different orthostatic responses of blood pressure (BP) and cerebral oxygenation than healthy elderly subjects. We investigated orthostatic changes in systemic haemodynamic variables and cerebral …

Transcranial oximetry using fast near infrared spectroscopy can detect failure of collateral blood supply in humans

We tested the hypothesis that transcranial oximetry by fast scanning near infrared spectroscopy can detect local desaturation of hemoglobin in arterial vessels of cerebral circulation with impaired blood supply. A total of 74 near infrared …

Reproducibility of orthostatic changes in cerebral oxygenation in healthy subjects aged 70 years or older

In the elderly, standing can frequently be accompanied by blood pressure (BP) changes and cerebral symptoms such as dizziness, fall, or even syncope, but this may vary from day-to-day. Therefore, we aimed to investigate the reproducibility of …

A comparative study of two near infrared spectrophotometers for the assessment of cerebral haemodynamics

Conventional near infrared spectroscopy (NIRS), introduced by Jobsis in 1977, can be considered as a reliable trend monitor for cerebral oxygenation. Quantisation, however, is complex and cumbersome. Recently a relatively simple system for cerebral …