High Intensity Intermittent Exercise Plays a Role in Improving Brain Activation During Complex Executive Functional Tasks

Several neuroimaging studies have examined the effect of different types and combinations of exercises on activation of brain associated with cognitive testing but none of these studies have examined the role of high intensity intermittent exercise …

High-intensity interval training vs. hydrochlorothiazide on blood pressure, cardiovascular health and cognition: Protocol of a non-inferiority trial

Background: While the number of people with hypertension (HBP) continues to increase, the therapeutic target for optimal blood pressure (BP) has been revised to a lower level. Studies have suggested that High-Intensity Interval Training (HIIT) could …

Age-related decline in visuo-spatial working memory is reflected by dorsolateral prefrontal activation and cognitive capabilities

Introduction: Visuo-spatial working memory (VSWM) performances undergo a decline throughout aging and are affected by the space in which the task is performed (reaching or navigational). Cerebral oxygenation and cognitive capabilities could explain …

Motor behavior-induced prefrontal cortex activation and episodic memory function

Background: The objective of this paper was to evaluate the potential individual and combined effects of acute exercise coupled with bilateral interhemispheric activation on episodic memory function. Six experiments were conducted. Methods: …

Levodopa Facilitates Prefrontal Cortex Activation During Dual Task Walking in Parkinson Disease

Background. Although dopaminergic medication improves dual task walking in people with Parkinson disease (PD), the underlying neural mechanisms are not yet fully understood. As prefrontal cognitive resources are involved in dual task walking, …

A Cross-species Model of Dual-Task Walking in Young and Older Humans and Rats

Introduction: Dual-task walking is common in daily life but becomes more difficult with aging. Little is known about the neurobiological mechanisms affecting competing cognitive demands. Translational studies with human and animal models are needed …

Combining Frontal Transcranial Direct Current Stimulation With Walking Rehabilitation to Enhance Mobility and Executive Function: A Pilot Clinical Trial

Objectives: This pilot study assessed whether frontal lobe transcranial direct current stimulation (tDCS) combined with complex walking rehabilitation is feasible, safe, and shows preliminary efficacy for improving walking and executive function. …

Prefrontal Cortex Activity and Gait in Parkinson's Disease With Cholinergic and Dopaminergic Therapy

Degradation of striatal dopamine in Parkinson's disease (PD) may initially be supplemented by increased cognitive control mediated by cholinergic mechanisms. Shift to cognitive control of walking can be quantified by prefrontal cortex activation. …

Cognitive performance is associated with cerebral oxygenation and peripheral oxygen saturation, but not plasma catecholamines, during graded normobaric hypoxia

New Findings: What is the central question of this study? What are the mechanisms responsible for the decline in cognitive performance following exposure to acute normobaric hypoxia? What are the main findings and their importance? We found that (1) …

Acute effects of combined Bacopa, American ginseng and whole coffee fruit on working memory and cerebral haemodynamic response of the prefrontal cortex: a double-blind, placebo-controlled study

Objective: This study assessed whether a multi-ingredient herbal supplement containing Bacopa monniera (BM), Panax quinquefolius ginseng (PQ) and whole coffee fruit extract (WCFE) could enhance cognitive performance and cerebral-cortical activation …

Exercise intensity influences prefrontal cortex oxygenation during cognitive testing

Activation changes in the prefrontal cortex (PFC) regions have been linked to acute exercise-induced improvements in cognitive performance. The type of exercise performed may influence PFC activation, and further impact cognitive function. The …

Repeated treadmill sprints impair cognitive performance in amateur team-sport athletes when performed in normobaric hypoxia

This study determined if a single bout of repeated-sprint running under hypoxic (RSH) conditions was associated with impaired cognitive function when compared with repeated-sprint running under normoxic (RSN) conditions. Eleven amateur team-sport …

The effect of severe and moderate hypoxia on exercise at a fixed level of perceived exertion

Purpose: The purpose of this study was to determine the primary cues regulating perceived effort and exercise performance using a fixed-RPE protocol in severe and moderate hypoxia. Methods: Eight male participants (26 ± 6 years, 76.3 ± 8.6 kg, 178.5 …

The effects of cardiorespiratory fitness on executive function and prefrontal oxygenation in older adults

Reviews on cardiovascular fitness and cognition in older adults suggest that a higher level of cardiorespiratory fitness may protect the brain against the effects of aging. Although studies reveal positive effects of cardiorespiratory fitness on …

Concurrent exergaming and transcranial direct current stimulation to improve balance in people with Parkinson's disease: Study protocol for a randomised controlled trial

Background: People with Parkinson's disease (PD) commonly experience postural instability, resulting in poor balance and an increased risk of falls. Exercise-based video gaming (exergaming) is a form of physical training that is delivered through …

The effect of zolpidem on cognitive function and postural control at high altitude

Study Objectives Sleep is altered at high altitude leading many mountaineers to use hypnotics in order to improve sleep efficiency. While after a full night at altitude the short-acting hypnotic zolpidem does not appear to alter cognitive function, …

When is Higher Level Cognitive Control Needed for Locomotor Tasks Among Patients with Parkinson's Disease?

Turning has been implicated as a complex task that requires both motor and cognitive resources. Accumulating evidence shows that patients with Parkinson's disease (PD) require more steps and more time to complete a turn, however, the role of the …

Acute cocoa flavanol improves cerebral oxygenation without enhancing executive function at rest or after exercise

Acute exercise-induced improvements in cognitive function are accompanied by increased (cerebral) blood flow and increased brain-derived neurotrophic factor (BDNF) levels. Acute cocoa flavanol (CF) intake may improve cognitive function, cerebral …

Dietary nitrate modulates cerebral blood flow parameters and cognitive performance in humans: A double-blind, placebo-controlled, crossover investigation

Nitrate derived from vegetables is consumed as part of a normal diet and is reduced endogenously via nitrite to nitric oxide. It has been shown to improve endothelial function, reduce blood pressure and the oxygen cost of sub-maximal exercise, and …

A double-blind, placebo-controlled study evaluating the effects of caffeine and L-theanine both alone and in combination on cerebral blood flow, cognition and mood

Abstract Rationale: Evidence suggests interactive effects of the tea components caffeine and L-theanine on behaviour, yet no data exists exploring the impact of the two on cerebral blood flow (CBF). Objectives: The current placebo-controlled, …