Study objectives: Effects of chronic metabolic alkalosis and acidosis and their relation to central chemoregulation may differ between normocapnic and chronic hypercapnic patients with COPD. The relationship between responses of inspired ventilation …

The relationship between alterations in cerebral blood volume (CBV) and central chemosensitivity regulation was studied under neutral metabolic conditions and during metabolic acidosis. Fifteen healthy subjects (56±10 years) were investigated. To …

The aim of this study was to induce acute metabolic acid/base changes of ≥ 2 mequiv ˙ l-1 change in base excess (BE) to aid future investigations of respiratory parameters under these conditions. Ammonium chloride (NH4Cl) was administered to induce …