Peripheral impairments of oxidative metabolism after a 10-day bed rest are upstream of mitochondrial respiration

In order to identify peripheral biomarkers of impaired oxidative metabolism during exercise following a 10-day bed rest, 10 males performed an incremental exercise (to determine peak pulmonary V˙O 2 (V˙O 2 p)) and moderate-intensity exercises, before …

Separate and combined effects of a 10-d exposure to hypoxia and inactivity on oxidative function in vivo and mitochondrial respiration ex vivo in humans

An integrative evaluation of oxidative metabolism was carried out in 9 healthy young men (age, 24.1 1.7 yr mean=SD) before (CTRL) and after a 10-day horizontal bed rest carried out in normoxia (N-BR) or hypoxia (H-BR, FIO2 0.147). H-BR was designed …

Changes in cerebral oxygenation during parabolic flight

Assessing changes in brain activity under extreme conditions like weightlessness is a desirable, but difficult undertaking. Results from previous studies report specific changes in brain activity connected to an increase or decrease in gravity …

Functional impairment of skeletal muscle oxidative metabolism during knee extension exercise after bed rest

A functional evaluation of skeletal muscle oxidative metabolism during dynamic knee extension (KE) incremental exercises was carried out following a 35-day bed rest (BR) (Valdoltra 2008 BR campaign). Nine young male volunteers (age: 23.5 ± 2.2 yr; …

Role of skeletal muscles impairment and brain oxygenation in limiting oxidative metabolism during exercise after bed rest

"Central" and "peripheral" limitations to oxidative metabolism during exercise were evaluated in 10 young males following a 35-day horizontal bed rest (BR). Incremental exercise (IE) and moderate- and heavy-intensity constant-load exercises (CLE) …