A Cross-species Model of Dual-Task Walking in Young and Older Humans and Rats

Introduction: Dual-task walking is common in daily life but becomes more difficult with aging. Little is known about the neurobiological mechanisms affecting competing cognitive demands. Translational studies with human and animal models are needed …

Combining Frontal Transcranial Direct Current Stimulation With Walking Rehabilitation to Enhance Mobility and Executive Function: A Pilot Clinical Trial

Objectives: This pilot study assessed whether frontal lobe transcranial direct current stimulation (tDCS) combined with complex walking rehabilitation is feasible, safe, and shows preliminary efficacy for improving walking and executive function. …

Pre-frontal cortical activity during walking and turning is reliable and differentiates across young, older adults and people with Parkinson's disease

Introduction: Mobility declines with age and further with neurodegenerative disorders, such as Parkinson's disease (PD). Walking and turning ability, in particular, are vital aspects of mobility that deteriorate with age and are further impaired in …

Treading on the unknown increases prefrontal activity: A pilot fNIRS study

Background: Complex walking conditions (e.g. dual tasking) have been associated with increased prefrontal (PFC) activity. However, most paradigms include a predictable environment, specifically, a predictable walking terrain. In the present study we …

Sex differences in the oxygen delivery, extraction, and uptake during moderate-walking exercise transition

Previous studies in children and older adults demonstrated faster oxygen uptake (VO2) kinetics in males compared with females, but young healthy adults have not been studied. We hypothesized that young men would have faster aerobic system dynamics in …