Acute effects of manual breathing assist technique on lung volume and dyspnea in individuals with severe chronic obstructive pulmonary disease: A quasi-experimental study

Background: Manual breathing assist technique (MBAT) is a common physical therapy technique used to facilitate airway clearance and improve ventilation and oxygenation. The effects during and immediately after intervention in individuals with chronic …

Association of Compensatory Mechanisms in Prefrontal Cortex and Impaired Anatomical Correlates in Semantic Verbal Fluency: A Functional Near-Infrared Spectroscopy Study

Objective Semantic verbal fluency (SVF) engages cognitive functions such as executive function, mental flexibility, and semantic memory. Left frontal and temporal lobes, particularly the left inferior frontal gyrus (IFG), are crucial for SVF. This …

Carbon monoxide Supplementation: Evaluating its Potential to Enhance Altitude Training Effects and Cycling Performance in Elite Athletes

Altitude training is a cornerstone for endurance athletes for improving blood variables and performance with optimal effects observed at ⁓2300-2500 meters above sea level (m.a.s.l.). However, elite cyclists face challenges such as limited access to …

Cerebral hemodynamic and systemic physiological changes in trained freedivers completing sled-assisted dives to two different depths

While existing literature covers significant detail on the physiology of human freediving, the lack of standardized protocols has hindered comparisons due to confounding variables such as exercise and depth. By accounting for these variables, direct …

Contributions to forearm desaturation during transient ischemia in healthy adult males and females across the lifespan

This study investigated skeletal muscle tissue oxygenation (StO2) desaturation in males and females across the adult lifespan. One-hundred-two individuals (51 females) of 41 young, 34 midlife, and 27 older adults completed a vascular occlusion test …

Differential impacts of body composition on oxygen kinetics and exercise tolerance of HFrEF and HFpEF patients

This study aims to (1) compare the kinetics of pulmonary oxygen uptake (VO2p), skeletal muscle deoxygenation ([HHb]), and microvascular O2 delivery (QO2mv) between heart failure (HF) patients with reduced ejection fraction (HFrEF) and those with …

Effect of Curcumin Intake on Skeletal Muscle Oxygen Saturation Parameters in Older Participants

Introduction: Aging is associated with increased reactive oxygen species (ROS) and reduced bioavailability of nitric oxide (NO). Curcumin has been shown to increase NO bioavailability due to its ability to neutralize ROS, preventing oxidative stress. …

Effectiveness of a game-based high-intensity interval training on executive function and other health indicators of children with ADHD: A three-arm partially-blinded randomized controlled trial

Background Children with ADHD demand for effective intervention with minimum side effect to improve executive function (EF) and health well-being. Method This study used a three-arm partially-blinded randomized controlled trial to test the effects of …

Effects of coffee intake on skeletal muscle microvascular reactivity at rest and oxygen extraction during exercise: a randomized cross-over trial

Purpose The effects of coffee ingestion on skeletal muscle microvascular function are not well understood. This study aimed to investigate the acute effects of coffee intake with varying levels of caffeine on skeletal muscle microvascular reactivity …

Freezing of gait in Parkinson's disease is related to imbalanced stopping–related cortical activity

Freezing of gait, characterized by involuntary interruptions of walking, is a debilitating motor symptom of Parkinson's disease that restricts people's autonomy. Previous brain imaging studies investigating the mechanisms underlying freezing were …

Influence of Running Velocity and Hypoxic Exposure on Vastus Lateralis Muscle Oxygenation

Purpose: We investigated the effects of manipulating running velocity and hypoxic exposure on vastus lateralis muscle oxygenation levels during treadmill running. Methods: Eleven trained male distance runners performed 7 randomized runs at different …

Investigating Cerebello-Frontal Circuits Associated with Emotional Prosody: A Double-Blind tDCS and fNIRS study

The emotional and cognitive cerebellum has been explored by several studies in the past years. Recent evidence suggested the possible contribution of the cerebellum in processing emotional prosody, namely the ability to comprehend the emotional …

Millimeter wave radiation to measure blood flow in healthy human subjects

Objective: Peripheral Artery Disease (PAD) is a progressive cardiovascular condition affecting 8-10 million adults in the United States. PAD elevates the risk of cardiovascular events, but up to 50% of people with PAD are asymptomatic and …

Reliability and Convergent Validity of Endurance Indices Derived from Near-Infrared Spectroscopy and Electromyography during a Bilateral Hanging Task in Amateur Rock Climbers

Background: The ability to hang for a long time before forearm muscle fatigue is a crucial element of successful rock climbing. Electromyography (EMG) and near-infrared spectroscopy (NIRS) are also useful for measuring hemoglobin oxygenation for …

Using mindfulness-based intervention to promote executive function in young children: a multivariable and multiscale sample entropy study

Early childhood marks a pivotal period in the maturation of executive function, the cognitive ability to consciously regulate actions and thoughts. Mindfulness-based interventions have shown promise in bolstering executive function in children. This …

A mechanistic understanding of cognitive performance deficits concurrent with vigorous intensity exercise

This study aimed to evaluate whether cerebral oxygenation of the prefrontal cortex and associative-dissociative focus while completing the task mediate changes in cognition during exercise. Seventy-five young college-aged adults participated in this …

Daily Physical Activity Does Not Contribute to Differences in Muscle Oxidative Capacity Between Overweight and Obesity

Background: The interaction between physical activity, skeletal muscle health, and adiposity has been explored in normal weight and overweight/obesity grouped together; however, the overall risks associated with being overweight are less than those …

Difference in expiratory flow limitations development in normoxia and hypoxia in healthy individuals

The present study investigated the maintenance/repeatability of expiratory flow limitation (EFL) between normoxia and hypoxia. Fifty-one healthy active individuals (27 men and 24 women) performed a lung function test and a maximal incremental …

Eight sessions of transcranial electrical stimulation for postural response in people with Parkinson’s disease: A randomized trial

Background Impairments in postural responses to perturbation are common in people with Parkinson’s disease (PwPD) and lack effective treatment. We recently showed that a single session of transcranial direct current stimulation (tDCS) promotes acute …

Near-infrared spectroscopy (NIRS) in vivo assessment of skeletal muscle oxidative capacity: a comparison of results from short versus long exercise protocols and reproducibility in non-athletic adults

Background: Near-infrared spectroscopy (NIRS) provides a non-invasive, cost-effective method for assessing skeletal muscle oxidative capacity when combined with a short exercise protocol and arterial occlusions. However, the impact of different …