A neuro-cardiac self-regulation therapy to improve autonomic and neural function after SCI: a randomized controlled trial protocol

Spinal cord injury (SCI) is associated with autonomic imbalance and significant secondary conditions, including cardiac and brain dysfunction that adversely impact health and wellbeing. This study will investigate the effectiveness …

Acute L-Citrulline Supplementation Increases Nitric Oxide Bioavailability but Not Inspiratory Muscle Oxygenation and Respiratory Performance

The present study aimed to investigate whether acute L-citrulline supplementation would affect inspiratory muscle oxygenation and respiratory performance. Twelve healthy males received 6 g of L-citrulline or placebo in a double-blind crossover …

Blood volume vs. deoxygenated NIRS signal: computational analysis of the effects muscle O 2 delivery and blood volume on the NIRS signals

Near-infrared spectroscopy (NIRS) signals quantify the oxygenated ($Δ$HbMbO 2 ) and deoxygenated ($Δ$HHbMb) heme group concentrations. $Δ$HHbMb has been preferred to $Δ$HbMbO 2 in evaluating skeletal muscle oxygen extraction because it is assumed to …

Effect of Climbing Speed on Pulmonary Oxygen Uptake and Muscle Oxygen Saturation Dynamics in the Finger Flexors

Purpose : Although sport climbing is a self-paced whole-body activity, speed varies with climbing style, and the effect of this on systemic and localized oxygen responses is not well understood. Therefore, the aim of the present study was to …

Effects of graded hypoxia during exhaustive intermittent cycling on subsequent exercise performance and neuromuscular responses

This study examined the effect of graded hypoxia during exhaustive intermittent cycling on subsequent exercise performance and neuromuscular fatigue characteristics in normoxia. Fifteen well-trained cyclists performed an exhaustive intermittent …

Men exhibit faster skeletal muscle tissue desaturation than women before and after a fatiguing handgrip

The purpose was to test the hypothesis that sex and fatigue effect of the early phase of skeletal muscle tissue oxygenation (StO2, %) desaturation rate as well as that strength matched adults may exhibit similar responses. Twenty-four adults visited …

Modifications in Prefrontal Cortex Oxygenation in Linear and Curvilinear Dual Task Walking: A Combined fNIRS and IMUs Study

Increased oxygenated hemoglobin concentration of the prefrontal cortex (PFC) has been observed during linear walking, particularly when there is a high attention demand on the task, like in dual-task (DT) paradigms. Despite the knowledge that …

Peripheral impairments of oxidative metabolism after a 10-day bed rest are upstream of mitochondrial respiration

In order to identify peripheral biomarkers of impaired oxidative metabolism during exercise following a 10-day bed rest, 10 males performed an incremental exercise (to determine peak pulmonary V˙O 2 (V˙O 2 p)) and moderate-intensity exercises, before …

Prefrontal Cortical Activity During Preferred and Fast Walking in Young and Older Adults: An fNIRS Study

Age-related changes may affect the performance during fast walking speed. Although, several studies have been focused on the contribution of the prefrontal cortex (PFC) during challenging walking tasks, the neural mechanism underling fast walking …

Running exercise with end-expiratory breath holding up to the breaking point induces large and early fall in muscle oxygenation

The goal of this study was to assess the effects of repeated running bouts with end-expiratory breath holding (EEBH) up to the breaking point on muscle oxygenation. Eight male runners participated in three randomised sessions each including two …

Supplemental Watermelon Juice Attenuates Acute Hyperglycemia-Induced Macro-and Microvascular Dysfunction in Healthy Adults

Background Acute hyperglycemia reduces NO bioavailability and causes macro- and microvascular dysfunction. Watermelon juice (WMJ) is a natural source of the amino acid citrulline, which is metabolized to form arginine for the NO cycle and may improve …

The Role of Deconditioning in the End-Stage Renal Disease Myopathy: Physical Exercise Improves Altered Resting Muscle Oxygen Consumption

Background: Skeletal muscle dysfunction and poor exercise tolerance are hallmarks of end-stage renal disease (ESRD). Noninvasively measured (near-infrared spectroscopy, NIRS) resting muscle oxygen consumption (rmVO2) is a biomarker of muscle …

Turmeric root extract supplementation improves pre-frontal cortex oxygenation and blood volume in older males and females: a randomised cross-over, placebo-controlled study

Ageing is associated with endothelial dysfunction and reduced cerebral blood flow and oxygenation. The present study aimed to investigate whether turmeric supplementation could improve cerebral oxygenation and blood volume during brain activation via …

A physiological and biomechanical investigation of three passive upper-extremity exoskeletons during simulated overhead work

The objective of this study was to evaluate three passive upper-extremity exoskeletons relative to a control condition. Twelve subjects performed an hour-long, simulated occupational task ina laboratory setting. Independent measures of exoskeleton, …

Fatigue-induced changes in knee-extensor torque complexity and muscle metabolic rate are dependent on joint angle

PurposeJoint angle is a significant determinant of neuromuscular and metabolic function. We tested the hypothesis that previously reported correlations between knee-extensor torque complexity and metabolic rate ( ṁVO2 ) would be conserved at reduced …

Partial pressure of oxygen in adipose tissue and its relationship with fatness in a natural animal model of extreme fat deposition, the grey seal

Excessive adiposity is associated with altered oxygen tension and comorbidities in humans. In contrast, marine mammals have high adiposity with no apparent detrimental effects. However, partial pressure of oxygen (Po2) in their subcutaneous adipose …

The Association Between Contrast-Enhanced Ultrasound and Near-Infrared Spectroscopy-Derived Measures of Calf Muscle Microvascular Responsiveness in Older Adults

Contrast-enhanced ultrasound (CEUS) measures of post-occlusion skeletal muscle microvascular responsiveness demonstrate the microvascular dysfunction associated with ageing and age-related disease. However, the accessibility of CEUS is limited by the …

Body mass-normalized moderate dose of dietary nitrate intake improves endothelial function and walking capacity in patients with peripheral artery disease

Peripheral artery disease (PAD) is characterized by the accumulation of atherosclerotic plaques in the lower extremity conduit arteries, which impairs blood flow and walking capacity. Dietary nitrate has been used to reduce blood pressure (BP) and …

Dual-task walking and automaticity after Stroke: Insights from a secondary analysis and imaging sub-study of a randomised controlled trial

Objective: To test the extent to which initial walking speed influences dual-task performance after walking intervention, hypothesising that slow walking speed affects automatic gait control, limiting executive resource availability. Design: A …

Effect of heat pre-conditioning on recovery following exercise-induced muscle damage

This study investigated the influence of heat pre-conditioning on the recovery of muscle torque, microvascular function, movement economy and stride mechanics following exercise-induced muscle damage (EIMD). Twenty male participants were equally …